this is literally not possible. while I'm excited for these kinds of things, alphafold is already imperfect, and this basically side-steps actual structural predictions. it sounds good, but frankly biology is not there yet. in practice not even alpha fold can tell me if my gfp fusion will work...
Meanwhile someone went and did the experiment on the equivalent problem in a virus: https://www.science.org/content/blog-post/mutate-em-all-and-...
And AI made poor predictions of the results of that experiment, which casts doubts about the value of the AlphaGenome predictive map.
the catch with a genome-wide map is the benchmark labels came from conservation, so you can't tell prediction from re-reading the prior.
> benchmark labels came from conservation
And from human disease...?
this is literally not possible. while I'm excited for these kinds of things, alphafold is already imperfect, and this basically side-steps actual structural predictions. it sounds good, but frankly biology is not there yet. in practice not even alpha fold can tell me if my gfp fusion will work...
Some more discussion: https://news.ycombinator.com/item?id=49611251