• 70 Use of Bayesian methodology in clinical trials of drug and biological products [pdf] (fda.gov)
  by brendanashworth 4 days ago | 21 comments
• 237 First impressions of Claude Cowork (simonw.substack.com)
  by stosssik 5 days ago | 140 comments
• 72 Show HN: 1Code – Open-source Cursor-like UI for Claude Code (github.com)
  by Bunas 4 days ago | 48 comments
• 75 Bringing the Predators to Life in MAME (lysiwyg.mataroa.blog)
  by msephton 6 days ago | 17 comments
• 316 GitHub should charge everyone $1 more per month to fund open source (blog.greg.technology)
  by evakhoury 5 days ago | 341 comments
• 15 Ask HN: How to bullet proof yourself from AI?
  by max_ a day ago | 16 comments ask
• 90 Show HN: Gambit, an open-source agent harness for building reliable AI agents (github.com)
  by randall 4 days ago | 23 comments
• 7 Why reinforcement learning plateaus without representation depth (NeurIPS 2025) (venturebeat.com)
  by brandonb 18 hours ago | 1 comments
• 36 When Sysadmins Ruled the Earth (2006) (craphound.com)
  by b112 a day ago | 2 comments
• 53 pf: Make af-to less magical (undeadly.org)
  by defrost 3 days ago | 15 comments
• 253 Raspberry Pi's New AI Hat Adds 8GB of RAM for Local LLMs (jeffgeerling.com)
  by ingve 4 days ago | 209 comments
• 30 Universal SSL exposes domains to BGP leaks (community.cloudflare.com)
  by 8organicbits 3 days ago | 1 comments
• 6 Serpl – a pleasant TUI for regex and fixed-string search and replace (github.com)
  by Curiositry 2 days ago | discuss
• 65 AV1 Image File Format Specification Gets an Upgrade with AVIF v1.2.0 (aomedia.org)
  by breve 2 days ago | 5 comments
• 268 Why senior engineers let bad projects fail (lalitm.com)
  by SupremumLimit 4 days ago | 162 comments
• 7 Fossgis 2026 – German language conference of FOSSGIS e.V. (OSGeo Local Chapter) (fossgis-konferenz.de)
  by slow_typist a day ago | discuss
• 61 Launching the Handmade Software Foundation (handmade.network)
  by DeathArrow a day ago | 39 comments
• 23 The Harvesting of Lettuce (sftw.substack.com)
  by HR01 a day ago | 3 comments
• 352 To those who fired or didn't hire tech writers because of AI (passo.uno)
  by theletterf 4 days ago | 264 comments
• 209 Data is the only moat (frontierai.substack.com)
  by cgwu 4 days ago | 47 comments
• 28 Building a Quake PC (fabiensanglard.net)
  by roskelld 3 days ago | 13 comments
• 37 We Gave Our Browser Agent a 3MB Data Warehouse (100x.bot)
  by shardullavekar 4 days ago | 5 comments
• 12 Pre-Agent Nostalgia (pcloadletter.dev)
  by ronbenton 16 hours ago | 5 comments
• 14 An explanation of cheating in Doom2 Deathmatch (1999) (doom2.net)
  by Lammy 2 days ago | 1 comments
• 185 JuiceFS is a distributed POSIX file system built on top of Redis and S3 (github.com)
  by tosh 4 days ago | 110 comments
• 8 The File System API is so underrated (davide.im)
  by vector3 a day ago | 6 comments
• 126 Native ZFS VDEV for Object Storage (OpenZFS Summit) (zettalane.com)
  by suprasam 5 days ago | 31 comments
• 27 Independent Guest Virtual Machine (IGVM) File Format (github.com)
  by ingve 4 days ago | 9 comments
• 36 Show HN: Microwave – Native iOS app for videos on ATproto (testflight.apple.com)
  by sinned 6 days ago | 10 comments
• 25 Artisanal Code (sunnyamrat.com)
  by sunnyam 3 days ago | 7 comments